Caroline’s research career spans from 2016. She joined the Centre for Infectious Disease Research in Zambia (CIDRZ). Caroline won an early career development grant from EDCTP,which investigated the immunogenicity of the new oral cholera vaccine introduced in Zambia forthe first time in 2016 during the cholera outbreak, with 3 manuscripts published on this work. An additional pump priming grant (BACTIVAC) allowed for further investigation into poor vaccine immune response with a special focus on memory B cells with further publications, most importantly showcasing for the first time in Zambia that cholera antibodies can be found in salivaas there is robust immune response post natural infection compared to vaccination.

Caroline was site PI in a multi-country clinical trial that investigated the rotavirus injectable vaccine (NRRV) in comparison with the oral Rotarix™ vaccine. She has supported severalclinical trials (ETEC, HIV, and Shigella vaccine trials) and studies within CIDRZ. She has also contributed to the establishment of the cholera vibriocidal assay for the first time in Zambia and the region. This platform has been used to train scientists from Cameroon, Sanger, UK, and Malawi. She has also been instrumental in setting up the cultured ELISPOTS in Zambia in collaboration with the African Health Research Institute (AHRI) in South Africa.

In addition to lecturing part-time, she has contributed to and supervised many MSc students and mentored over 15 PhD students. Caroline is being mentored by Professor David Sack and Nick Thomson, who are renowned cholera experts and were recently nominated to be Technical Advisors on the Ministry of Health cholera technical working group (TWG). Her postdoctoral work continues to expand on the genetics and immunogenicity of various cholera vaccines.