Agnes Mutua
Supervisors
Prof. Amina Abubakar
Prof. Amina Abubakar
Email : AAbubakar@kemri-wellcome.org Amina is an Associate Professor of Psychology and Public Health at Pwani University, Kenya and a Research Fellow at the Kenya Medical Research Institute/Wellcome Trust Research Programme. She co-leads the Neuroscience research group at KEMRI-WTRP. She is also an honorary fellow at the Department of Psychiatry, University of Oxford, UK. She holds the prestigious MRC/DfiD African Research Leaders award. In 2016, she was awarded the Royal Society Pfizer Award. Her main interests are in the study of developmental delays and impairments among children exposed to various health problems such as HIV, malnutrition and malaria. A focus in her work is the development of culturally appropriate strategies for identifying, monitoring and rehabilitating at-risk children. Prof Abubakar has been instrumental in developing various culturally appropriate measures of child development that have been used in many African countries. In addition, she is also interested in examining the prevalence of and risk factors for neurodevelopmental disorders, specifically ASD, within the African context. Prof. Abubakar has given guest lectures, and workshops largely focusing on cross-cultural research methods in various countries, including Cameroon, Germany, Indonesia, Kenya, the Netherlands, New Zealand, South Africa, and Spain. She has (co)-authored more than 80 peer-reviewed journal articles and book chapters. She has served on technical working groups, and forums for various international organizations including the World Health Organization, National Academies of Sciences, Engineering and Medicine (USA), Save the Children, and Autism Speaks. She is actively involved in capacity building for African Scientists; she has supervised Postgraduate Diploma, Masters and PhD students in Kenya. She has also supervised PhD students from South Africa, Tanzania and Zambia.
Dr. Sara Atkinson
Email : SAtkinson@kemri-wellcome.org Biography
I am a Senior Lecturer and Honorary Consultant in Paediatric Infectious Disease in the Department of Paediatrics at the University of Oxford and at the KEMRI-Wellcome Trust Research Programme (KWTRP) in Kilifi, Kenya. I received my medical degree from Guy’s and St Thomas’ Medical School in London and completed clinical training in London, Newcastle and Oxford. My PhD was based at LSHTM and MRC, The Gambia. I first came to KWTRP as a Clinical Research Fellow in 2004 before being appointed as a Clinical Lecturer in Paediatrics at the University of Oxford in 2007. I have been based at KWTRP since 2013.
Research
Both infectious diseases and micronutrient deficiencies are widespread among children living in sub-Saharan Africa. My research questions concern the impact that infections and nutrient deficiencies have on each other. For example: could malaria and other infections be a causal factor in the widespread prevalence of iron deficiency in African children? We found that iron deficiency increases markedly over a malaria season. The hormone hepcidin, the master iron regulator, prevents iron absorption and recycling leading to low iron levels. We found that even asymptomatic malaria infection strongly induces hepcidin in Kenyan children. We are using genetic and epidemiological methods to investigate the impact of malaria on iron deficiency. It is possible that elimination of malaria may also prevent an important cause of iron deficiency for children living in sub-Saharan Africa.
The safety of iron supplementation is an important concern as studies suggest that iron deficiency protects children from malaria and other infections. I am using a Mendelian randomization (MR) approach to address the question of whether a child’s iron status is causally related to their risk of severe malaria and/or bacteraemia. MR is an approach that utilizes the random allocation of genetic variants at conception to investigate causality between an intermediate trait (iron status) and disease (severe infection). In order to identify genetic variants for use in MR, I am conducting the first GWAS study of iron status (including hepcidin) in African populations. Validated genetic variants will be taken forward to large MR case-control studies of severe malaria and bacteraemia using stored samples from the Kilifi Biobank and the MalariaGEN Consortium.
Agnes is a results-oriented, energetic, early career researcher, who is passionate about applying health research to address critical questions in public health, to prevent premature death and disability. She enjoys travelling, playing volleyball and mentoring young children.
She graduated from Kenyatta university with a Bachelor of Science degree in Environmental health. She worked for 2 years under the Ministry of Health (Kenya) and gained in-depth experience in public health operations including community nutrition and disease surveillance. She is currently undertaking an integrated review of literature, to determine whether lack of adequate Iron and vitamin D during early childhood, has any effect on child development, in the short and long term. She is looking forward to being involved in health research programs in Kenya and beyond, that are aimed at finding practical solutions to a myriad of health problems affecting the community.
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